Rodent-associated Bartonella Febrile Illness, Southwestern United States
نویسندگان
چکیده
Serum specimens from 114 patients hospitalized with a febrile illness were tested with an indirect immunofluorescence assay (IFA) using Bartonella antigens prepared from 6 species of sigmodontine rodents and 3 known human Bartonella pathogens: B. henselae, B. quintana, and B. elizabethae. Acute- and convalescent-phase serum samples from 5 of these patients showed seroconversion with an IFA titer >512 to rodent-associated Bartonella antigens. The highest titer was against antigen derived from the white-throated woodrat (Neotoma albigula), although this rodent is not necessarily implicated as the source of infection. Three of the 5 who seroconverted showed no cross-reaction to the 3 Bartonella human pathogens. Common clinical characteristics were fever, chills, myalgias, leukopenia, thrombocytopenia, and transaminasemia. Although antibodies to Bartonella are cross-reactive, high-titer seroconversions to rodent-associated Bartonella antigens in adults with common clinical characteristics should stimulate the search for additional Bartonella human pathogens.
منابع مشابه
Hantavirus Pulmonar Syndrome: A Zebra Worth Knowing -- American Family Physician
www.aafp.org/afp AMERICAN FAMILY PHYSICIAN 1015 omyscus maniculatus), one of the most common small mammals in the United States. Additionally, the cotton rat and rice rat are the rodent vectors in the southeastern United States for the Black Creek Canal and Bayou viruses, respectively; the whitefooted mouse carries the New York virus in the northeast. Before 1993, illness caused by hantaviral i...
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References 1. Childs JE, Ksiazek TG, Spiropoulou CF, Krebs JW, Morzunov S, Maupin GO, et al. Serologic and genetic identification of Peromyscus maniculatus as the primary rodent reservoir for a new hantavirus in the southwestern United States. J Infect Dis 1994;169:1271-80. 2. Glass GE, Johnson JS, Hodenbach GA, DiSalvo LJ, Peters CJ, Childs JE, et al. Experimental evaluation of rodent exclusio...
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